Tabernaemontana corymbosa Roxb. ex Wall.

Last updated: 21 April 2016

Scientific Name

Tabernaemontana corymbosa Roxb. ex Wall.

Synonyms

Ervatamia baviensis (Pit.) Pichon, Ervatamia chinensis (Merr.) Tsiang, Ervatamia continentalis Tsiang, Ervatamia hirta (Hook.f.) King & Gamble, Ervatamia inaequalifolia (Lütjeh. & Ooststr.) Pichon, Ervatamia jasminiflora Ridl., Ervatamia kwangsiensis Tsiang, Ervatamia kweichowensis Tsiang, Ervatamia lamdongensis Lý, Ervatamia laotica (Pit.) Pichon, Ervatamia pauciflora Ridl., Ervatamia phuongii Lý, Ervatamia tenuiflora Tsiang, Ervatamia yunnanensis Tsiang, Pagiantha corymbosa (Roxb. ex Wall.) Markgr., Pagiantha peninsularis Kerr, Pseudixora sumatrana Miq., Randia sumatrana (Miq.) Miq., Tabernaemontana baviensis Pit., Tabernaemontana carinata Lütjeh. & Ooststr., Tabernaemontana chinensis Merr., Tabernaemontana continentalis (Tsiang) P.T.Li, Tabernaemontana cymulosa Miq., Tabernaemontana hirta Hook.f., Tabernaemontana inaequalifolia Lütjeh. & Ooststr., Tabernaemontana kwangsiensis (Tsiang) P.T.Li, Tabernaemontana kweichowensis (Tsiang) P.T.Li, Tabernaemontana laotica Pit., Tabernaemontana peninsularis (Kerr) P.T.Li, Tabernaemontana pubituba Merr., Tabernaemontana sumatrana (Miq.) Hallier f., Tabernaemontana sumatrana Merr. [Illegitimate], Tabernaemontana tsiangiana P.T.Li, Tabernaemontana yunnanensis (Tsiang) P.T.Li. [1]

Vernacular Name

Malaysia Jelutong badak, susun kelapa, susok ayam, pokok restung [2][3], restong badak, seratong, pokok setong, chanting badak, sembor badak, tandok-tandok, merambong paya [3]
English Pinwheel flower, flower of love [4]
China San fang gou ya hua [2]
Indonesia Djelutung badak, resting badak [2]
Thailand Sang laa [2]
Vietnam I[af]I tr[aa]u t[as]n [2].

Geographical Distributions

No documentation.

Botanical Description

Tabernaemontana corymbosa is a member of the Apocynaceae family. It is a shrub or small tree. [5]

The leaves are elliptic (15-40cm long) and coriaceous. The petiole base is enlarge and clasping the stem. The corymbs are in the upper axils, much branched. [5]

The corolla is cream white, follicles ovoid, curved, beaked, and 3.5-4cm long. [5]

Cultivation

No documentation.

Chemical Constituent

T. corymbosa  has been reported to contain 3R/S-ethoxyheyneanine, 3R/S-ethoxy-19-epi-heyneanine, 7(R)- geissoschizol oxindole, 7(S)-geissoschizol oxindole, 7(R),16(R)- 19(E)-isositsirikine oxindole, 7(S),16(R)-19(E)-isositsirikine oxindole, 19'(S)-hydroxyconodurine, 19'(S)-hydroxyconoduramine, 19'(S)-hydroxyervahanine A, 19(S)-hydroxyibogamine, 19-epi-isovoacristine, 19’(S) hydroconoduramin, 19’(S)-hydroxyyervahanine A, N(4)-demethyltaberpsychine,  conodiparines A-F, conodurine, conodurinine, conodutarines A and B, cononitarines A and B, ervahanine A, isovoacryptine, jerantinine A – H, jerantiphyllines A and B, tabersonine hydroxyindolenine, and vincamine. [6][7][8][9][10][11][12][13]

Plant Part Used

Bark, leaves, and roots. [6]

Traditional Use

In China, the bark and leaves are used for the treatment of fractures. The roots are used in Malaysia to recover from childbirth and exhaustion, and a paste of the plant is used to treat orchitis. [6][14]

The plant is used in the treatment of ulceration of the nose in tertiary syphilis (restung). [14]

Preclinical Data

Pharmacology

Cytotoxic activity

Five alkaloids (jerantinines A-E) isolated from T. corymbosa showed pronounced in vitro cytotoxicity against human KB cells (IC50<1µg/mL). Conodiparines showed significant activity in reversing resistance in vincristine-resistant KB cells. [9][13]

Toxicity

No documentation.

Clinical Data

No documentation.

Dosage

No documentation.

Poisonous Management

No documentation.

Line drawing

No documentation.

References

  1. The Plant List.  Ver1.1. Tabernaemontana corymbosa Roxb. ex Wall. [homepage on the Internet]. c2013 [updated 2012 Mar 23; cited 2016 Apr 20]. Available from: http://www.theplantlist.org/tpl1.1/record/kew-200648
  2. Quattrocchi U. CRC world dictionary of medicinal and poisonous plants: Common names, scientific names, eponyms, synonyms, and etymology. Volume V R-Z. Boca Raton, Florida: CRC Press, 2012; p. 484.
  3. Herbal Medicine Research Centre, Institute for Medical Research. Compendium of medicinal plants used in Malaysia. Volume 2. Kuala Lumpur: HMRC IMR, 2002; p. 375.
  4. Juwita Ratnasari SP. Galeri tanaman hias bunga. Jakarta: Penebar Swadaya, 2007; p. 205.
  5. Keng H. The concise flora of Singapore: Gymnosperms and dicotyledons Volume 1. Singapore: Singapore University Press, 1990; p. 145.
  6. Wiart C. Ethnopharmacology of medicinal plants: Asia and the Pacific. Berlin: Springer-Verlag, 2006; p. 74.
  7. Lim KH, Sim KM, Tan GH, Kam TS. Four tetracyclic oxindole alkaloids and a taberpsychine derivative from a Malayan Tabernaemontana. Phytochemistry. 2009;70(9):1182-1186.
  8. Lim KH, Thomas NF, Abdullah Z, Kam TS. Seco-tabersonine alkaloids from Tabernaemontana corymbosa. Phytochemistry. 2009;70(3):424-429.
  9. Lim KH, Hiraku O, Komiyama K, Kam TS. Jerantinines A-G, cytotoxic Aspidosperma alkaloids from Tabernaemontana corymbosa. J Nat Prod. 2008 Sep;71(9):1591-1594.
  10. Kam TS, Sim KM. Conodurine, conoduramine, and ervahanine derivatives from Tabernaemontana corymbosa. Phytochemistry. 2003;63(5):625-629.
  11. Kam TS, Sim KM, Pang HS. New bisindole alkaloids from Tabernaemontana corymbosa. J Nat Prod. 2003;66(1):11-16.
  12. Kam TS, Sim KM. Five new iboga alkaloids from Tabernaemontana corymbosa. J Nat Prod. 2002;65(5):669-672.
  13. Kam TS, Sim KM, Koyano T, Toyoshima M, Hayashi M, Komiyama K. Conodiparines A-D, new bisindoles from Tabernaemontana. Reversal of vincristine-resistance with cultured cells. Bioorg Med Chem Lett. 1998;8(13):1693-1696.
  14. Burkill IH. A dictionary of the economic products of the Malay Peninsula. Volume 1. London: Published on behalf of the governments of the Straits settlements and Federated Malay states by the Crown agents for the colonies, 1935; p. 942.