Tanacetum parthenium (L.) Sch.Bip.

Last updated: 25 May 2017

Scientific Name

Tanacetum parthenium (L.) Sch.Bip.  

Synonyms

Chamaemelum parthenium (L.) E.H.L.Krause, Chrysanthemum parthenium (L.) Pers. [Illegitimate], Chrysanthemum parthenium (L.) Bernh., Chrsanthemum praealtum Vent., Dendranthema parthenium (L.) Des Moul., Leucanthemum odoratum Dulac, Leucanthemum parthenium (L.) Gren. & Godr., Matricaria latifolia Gilib. [Invalid], Matricaria parthenium L., Parthenium matricaria Gueldenst., Parthenium matricaria gesn. ex Rupr., Pontia matricaria Bubani, Pyrethrum buschianum Sosn., Pyrethrum demetrii Manden., Pyrethrum divaricatum (Sosn.) Sosn., Pyrethrum glanduliferum Sommier & Levier, Pyrethrum grossheimii Sosn., Pyrethrum matricaria gesn. ex Rupr., Pyrethrum parthenium (L.) J.E.Smith, Pyrethrum parthenium (L.) Sm., Pyrethrum sericeum var. divaricatum (Sosn.) Sosn., Pyrethrum sevanenses Sosn. ex Grossh., Tanacetum demetrii (Manden.) K.Bremer & Humphries [Unresolved], Tanacetum glanduliferum (Sommier & Levier) K.Bremer & Humphries [Unresolved], Tanacetum grossheimii (Sosn.) Muradyan, Tanacetum savanenses (Sosn. ex Grossh.) K.Bremer & Humphries [Unresolved]. [1]

Vernacular Name

English Feverfew [2]
France Grande camomile, pyrèthre doré [2]
Spain Altamisa [2]
German Frauen-wucherblume, mutterkraut, moederkruid [2]
Denmark Matrem [2]
Norway Matrem [2]
Sweden Mattram [2]
Finland Reunuspietaryrtii [2].

Geographical Distributions

Tanacetum parthenium was found to distribute in North Africa, South East and East Europe, South West Asia from Turkey to Caucasus, Iran, Afghanistan, Pakistan (Baluchistan, N.W.F. Province); Kashmir and Central Asia; also widely naturalized in many countries. [3]

Botanical Description

T. parthenium is a member of Compositae family. [1] It is a perennial plant that are (20–)30–60(–80) cm tall. [3]

Stems 1–3+ (ridged), erect, branched (usually glabrous proximally, puberulent distally). Leaves mainly cauline; petiolate; blades ovate to rounded-deltate, 4–10+ × 1.5–4 cm, usually 1–2-pinnately lobed (primary lobes 3–5+ pairs, ± ovate), ultimate margins pinnatifid to dentate, faces (at least abaxial) usually puberulent, gland-dotted. Heads 5–20(–30) in corymbiform arrays. Involucres 5–7 mm diameter. Ray florets 10–21+ (more in "doubles"), pistillate, fertile; corollas white, laminae 2–8(–12) mm. Disc corollas ca. 2 mm. Cypselae ± columnar, 1–2 mm, 5–10-ribbed; pappi 0 or coroniform, 0.1–0.2+ mm. [3]

Cultivation

No documentation.

Chemical Constituent

No documentation.

Plant Part Used

No documentation.

Traditional Use

No documentation.

Preclinical Data

Pharmacology

Neuroprotective activity

Studies suggest that T. parthenium inhibits a number of chemical interactions that lead to the development of migraine headaches. [4][5][6][7][8]

Chloroform extract of T. parthenium leaves may also help prevent the contraction of smooth muscle tissues that cause migraine pain. [9]

Anti-inflammatory activity

T. parthenium extract was found to exhibit anti-inflammatory activity by inhibition of ADP, thrombin, or collagen-induced aggregation of human platelets, but significantly, did not affect aggregation induced by arachidonic acid. [10]

Toxicity

No documentation.

Clinical Data

Clinical findings

Anti rheumatoid arthritis activity

Forty one female patients with symptomatic rheumatoid arthritis received either dried chopped T. parthenium (70-86 mg) or placebo capsules once daily for six weeks shows no apparent benefit from oral administration of T. parthenium. [11]

Precautions

This dietary supplement is considered safe when used in accordance with proper dosing guidelines. [12]

If used to treat migraines, abrupt discontinuation of this dietary supplement may trigger a migraine headache. [13]

If you are planning to have any type of surgery or dental work, stop using this dietary supplement for at least 14 days prior to the procedure. [14]

If you have a bleeding disorder, talk to your doctor before taking this dietary supplement. [15]

Side effects

Some individuals experience an allergic reaction when taking this dietary supplement. Do not use this dietary supplement if you are allergic to pyrethrums. Use with caution if you have a severe ragweed allergy or allergy to members of the daisy and chrysanthemum family. Call your doctor or seek medical attention if you have fast or irregular breathing, skin rash, hives or itching. [16]

Pregnancy/Breast Feeding

This dietary supplement should not be used in pregnant women. [12]

Age limitation

No documentation.

Adverse reaction

No documentation.

Interaction & Depletion

Interaction with drug

Studies have reported that T. parthenium affects the blood's clotting ability and may alter the effects of these medications and possibly the dose needed for treatment. These drugs include warfarin, heparin, dalteparin, tinzaparin, enoxaparin, danaparoid sodium, antithrombin III, lipirudin, argatroban, bivalirudin, aspirin, dipyridamole, anagrelide, cilostazol, clopidogrel, ticlopidine, abciximab, tirofiban, and eptifibatide. [5][17]

Interaction with other Herbs

No documentation.

Contraindications

No documentation.

Dosage

Dosage Range

Standardized extract of T. parthenium is 100-250 mg, 1-3 times a day. [18][19]

1 to 3 leaves (25 to 75 mg), 1-2 times daily has been recommended. [18][19]

Most Common Dosage

No documentation.

Standardisation

No documentation.

Poisonous Management

No documentation.

Line drawing

No documentation.

References

  1. The Plant List. Ver1.1. Tanacetum parthenium (L.) Sch. Bip. [homepage on the Internet]. c2013 [updated 2012 Feb 11; cited 2017 May 25]. Available from: http://www.theplantlist.org/tpl1.1/record/gcc-36373.
  2. Global Biodiversity Information Facility (GBIF). Tanacetum parthenium (L.) Sch.Bip. [homepage on the Internet]. c2016 [cited 2017 May 25]. Available from: http://www.gbif.org/species/3118430/vernaculars.
  3. Encyclopedia of Life. Tanacetum parthenium (Golden feverfew). [homepage on the Internet]. No date [cited 2017 May 25]. Available from: http://www.eol.org/pages/468397/details.
  4. Hayes NA, Foreman JC. The activity of compounds extracted from feverfew on histamine release from rat mast cells. J Pharm Pharmacol. 1987;39(6):466-470.
  5. Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol. 1990;42(8):553-557.
  6. Capasson F. The effect of an aqueous extract of Tanacetum paethenium L. on arachidonic acid metabolism by rat peritoneal leucocytes. J Pharm Pharmacol. 1986;38(1):71-72.
  7. Béjar E. Parthenolide inhibits the contractile responses of rat stomach fundus to fenfluramine and dextroamphetamine but not serotonin. J Ethnopharmacol. 1996;50(1):1-12.
  8. Prusiński A, Durko A, Niczyporuk-Turek A. [Feverfew as aprophylactic treatment of migraine]. Neurol Neurochir Pol. 1999;33(Suppl 5):89-95.
  9. Barsby RW, Salan U, Knight DW, Hoult JR. Feverfew extracts and parthenolide irreversibly inhibit vascular responses of the rabbit aorta. J Pharm Pharmacol. 1992;44(9):737-740.
  10. Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med. 1982;8(6):653-660.
  11. Pattrick M, Heptinstall S, Doherty M. Feverfew in rheumatoid arthritis: A double blind, placebo controlled study. Ann Threum Dis. 1989;48(7):547-549.
  12. Newall CA. Herbal medicines: A guide for health care professionals. London: The Pharmaceutical Press, 1996; p. 119-121.
  13. Thomson Staff. PDR for herbal medicines-2nd edition. Montvale, NJ: Medical Economics Company, 2000; p. 307.
  14. Pribitkin ED, Boger G. Herbal therapy: What every facial plastic surgeon must know. Arch Facial Plast Surg. 2001;3(2):127-132.
  15. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57(13):1221-1227.
  16. Schmidt RJ. Plant dermatitis. Compositae. Clin Dermatol. 1986;4(2):46-61.
  17. Biggs MJ, Johnson ES, Persaud NP, Ratcliffe DM. Platelet aggregation in patients using feverfew for migraine. Lancet. 1982;2(8301):776.
  18. Johnson ES, kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew as prophylactic treatment of migraine. Br Med J (Clin Res Ed). 1985;291(6495):569-573.
  19. O’Hara M, Kiefer D, Farrell K, Kemper K. A review of 12 commonly used medicinal herbs. Arch Fam Med. 1998;7(6):523-536.