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Articles

Arabinoxylane

Plant Part Used

Mycelia extract.

Introduction

Mushrooms have been recognized for their medicinal properties for over five millennia, but it was not until recently that scientists figured out a way to extract the most active components of medicinal mushrooms. Arabinoxylane is one such extract. In fact, it consists of a combination of extracts from three different medicinal mushrooms: shiitake, kawaratake, and suehirotake. All three are known for their potential ability to support the immune system. These medicinal mushrooms also show promise as a supportive therapy for conditions such as cancer and HIV. (1)

Interactions and Depletions

Interactions

Dosage Info

Dosage Range

General immune support: 2 x 250mg capsules, 2-3 times a day.

Aggressive therapy: 4 x 250mg, 3-4 times a day for 2- 4 weeks, then 2 x 250mg, 2-3 times a day thereafter.

Most Common Dosage

General immune support: 2 x 250mg, 2 times a day.

Aggressive therapy: 4 x 250mg, 4 times a day for 4 weeks, then 2 x 250mg, 2 times a day.

 

Standardization

Standardization represents the complete body of information and controls that serve to enhance the batch to batch consistency of a botanical product, including but not limited to the presence of a marker compound at a defined level or within a defined range.

Not applicable.

Reported Uses

Arabinoxylane improves the body’s immunity, specifically the activity of the Natural Killer (NK) cells within the body. (2) , (3) These NK cells play a crucial role in resistance to viral infections and overall regulation of the immune system. Arabinoxylane’s immune-boosting properties have even been used to help inhibit the AIDS virus. (4)

Arabinoxylane may also help prevent the formation of tumors and certain kinds of cancer, (5) as well as ease some of the symptoms of chemotherapy for cancer patients. (6)

Toxicities & Precautions

Introduction

Be sure to tell your pharmacist, doctor, or other health care providers about any dietary supplements you are taking. There may be a potential for interactions or side effects.

General

This dietary supplement is considered safe when used in accordance with proper dosing guidelines.

Allergy

Some individuals experience an allergic reaction when taking this dietary supplement. People who are allergic to mushrooms should consult a doctor before use. Call your doctor or seek medical attention if you have fast or irregular breathing, skin rash, hives or itching.

Health Conditions

If you have kidney failure, talk to your doctor before taking this dietary supplement.

Pregnancy/ Breast Feeding

To date, the medical literature has not reported any adverse effects related to fetal development during pregnancy or to infants who are breast-fed. Yet little is known about the use of this dietary supplement while pregnant or breast-feeding. Therefore, it is recommended that you inform your healthcare practitioner of any dietary supplements you are using while pregnant or breast-feeding.

Age Limitations

To date, the medical literature has not reported any adverse effects specifically related to the use of this dietary supplement in children. Since young children may have undiagnosed allergies or medical conditions, this dietary supplement should not be used in children under 10 years of age unless recommended by a physician.

References

  1. View Abstract: Ghoneum M. Anti-HIV activity in vitro of MGN-3, an activated arabinoxylane from rice bran. Biochem Biophys Res Commun. Feb1998;243(1):25-9.
  2. View Abstract: Ghoneum M, et al. NK IMMUNOMODULATORY FUNCTION IN 27 CANCER PATIENTS BY MGN-3, A MODIFIED ARABINOXYLANE FROM RICE BRAN, 87th Annual Meeting of the American Association for Cancer Research. Washington DC. Apr1996.
  3. View Abstract: Ghoneum M. ENHANCEMENT OF HUMAN NATURAL KILLER CELL ACTIVITY BY MODIFIED ARABINOXYLANE FROM RICE BRAN (MGN-3). INTERNATIONAL JOURNAL OF IMMUNOTHERAPY XIV(i). 1998;89-99.
  4. View Abstract: Ghoneum M. Anti-HIV activity in vitro of MGN-3, an activated arabinoxylane from rice bran. Biochem Biophys Res Commun. Feb1998;243(1):25-9.
  5. View Abstract: Ghoneum M, et al. EFFECT OF MGN-3 ON HUMAN NATURAL KILLER CELL ACTIVITY AND INTERFERON- y SYNTHESIS IN VITRO. FASEB JOURNAL. Jun1996;26.
  6. Williams DG. A new chapter in healing. Alternatives. 1998;7:113-120.