Pereskia bleo (Kunth) DC.

Synonyms

Pereskia panamensis, P. corrugata, Rhodocactus corrugatus

Vernacular Names:

Malaysia Jarum tujuh bilah
English Leaf cactus, rose cactus, wax rose
Chinese Cak Sing Cam

 

General Information

Description

Pereskia bleo, a member of the Cactaceae family, is a spiny shrub which grows to a height of 2-8 m, having distinct orange-red flowers. A native to Central America, it is usually known as an ornamental plant. It has been cultivated in Malaysia for decorative and medicinal purposes (1).

Plant Part Used

Leaf (2).

Chemical Constutuents

Four alkaloids were isolated from P.bleo plant: 3,4-dimethoxy-β-phenethylamine, mescaline, 3-methoxytyramine and tyramine (3).

Recently, another four compounds were isolated from ethyl acetate fraction of its fresh leaves: phytol, β-sitosterol, 2,4-di-tert-butylphenol and vitamin E (4).

Traditional Use:

The leaves can be eaten raw as salad or taken as a concoction brewed from fresh plant. It is believed to have anti-cancer property and also as a remedy for the relief of gastric pain (1).

Pre-Clinical Data

Pharmacology

A methanol extract of P.bleo induces apoptosis in breast carcinoma, T 47-D cell lines with EC50 of 2.0 µg mL-1. This report suggests that the extract may contain bioactive compounds that kill breast carcinoma cells via the activation of caspase-3 and c-myc pathways (5).

A more recent investigation on the cytotoxic effects of the methanol extract and ethyl acetate fraction of P.bleo against selected human cancer cell lines, using in vitro red cytotoxicity assay, found that both possess high IC50 values of 6.5 and 4.5 mg mL-1, respectively (4).

Toxicities:

No documentation

Clinical Data

Clinical Trials

No documentation

Adverse Effetcs in Human:

No documentation

Use in Certain Conditions:

Pregnancy / Breastfeeding

No documentation

Age Limitations

Neonates / Adolescents

No documentation

Geriatrics

No documentation

Chronic Disease Conditions

No documentation

Interactions

Interactions with Drugs

No documentation

Interactions with Other Herbs / Herbal Constituents

No documentation

Contradications

Contraindications

No documentation

Case Reports

No documentation

References

  1. View Abstract: Medicinal Plants of the Asia-Pacific: Drugs for the Future? . 2006, World Scientific Publishing Co. Pte. Ltd., Singapore .
  2. Compendium of Medicinal Plants Used in Malaysia. 2002, Institute for Medical Research.
  3. View Abstract: Doetsch, P. . Cactus alkaloids XL. Identification of mescaline and other β-phenethylamine in Pereskia, Pereskiopsis and Islaya by use of fluorescamine conjugates. . J. Chromatograph. 1980; 189: 79-85
  4. View Abstract: Sri Nurestri Abdul Malik. Cytotoxic Activity of Pereskia bleo (Cactaceae) Against Selected Human Cell Lines. . Int. J. Cancer Res. . 2007; 189: 1-7
  5. View Abstract: Tan, M.L.. Methanol extract of Pereskia bleo (Kunth) DC (Cactaceae) induces apoptosis in breast canrcinoma, T47-D cell line. . J. Ethnopharmacol. 2005; 96: 287-294