How Vitamin B2 interacts with Tricyclic antidepressants

Interaction type: Interactions

Interaction rating: Study Supported

Amitriptyline and imipramine inhibit the conversion of riboflavin to its active form, flavin adenine dinucleotide in rat heart tissue. Supplementation with the affected nutrient may be necessary. (1)

These drugs include amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, protryptiline, trimipramine


  1. View Abstract: Pinto J, Huang YP, Pelliccione N, et al. Cardiac Sensitivity to the Inhibitory Effects of Chlorpromazine, Imipramine and Amitriptyline Upon Formation of Flavins. Biochem Pharmacol. Nov1982;31(21):3495-9.